Climate change has impacted people worldwide. In some places its impact can lead to natural disasters, while in others it leads to extremes of heat or cold. Particularly vulnerable groups like pregnant women, infants, frontline health workers and older citizens can be significantly affected by these changes. The EU-funded HIGH Horizons project aims to better prepare us for these eventualities by developing personalised early warning systems, studying the impact of extreme heat on vulnerable groups and preparing health facilities to assist them.