Local bacteriophages and probiotic Bacillus spp. will be isolated and characterized. The isolates wil be tested against Aeromonas hydrophila, both in vivo and in vitro under lab conditions. Bacillus spp. will be combined together with selected bacteriophages to test for a synergistic effect under lab conditions. Semi-field trials will conducted on Nile tilapia (Oreochromis niloticus) for field verification.